چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background:cyclooxygenase-2 (cox-2) is involved in pathogenesis of various tumors and possibly malignant skin tumors including malignant melanoma; however, there is not enough information about cox-2 expression in benign melanocytic lesions. In the present study we compared the expression levels of cox-2in malignant melanoma and benign melanocytic lesions. Methods: In this analytical study, 42 malignant melanoma from all 4 subtypes and 38 benign melanocytic lesions including dysplastic nevus, Spitz nevus and atypical nevus were evaluated for cox-2expression using immunohistochemistry staining and intensity of cell staining (quantitatively and qualitatively). Results: Malignant melanoma compared to benign melanocytic lesions had significantly higher levels of staining (p<0.001), and much more intense coloration (p<0.001) and higher overall staining score (p<0.001). Regarding the cox-2 stainingbetween malignant melanoma subtypes, all four subtypes mostly had staining intensity over 60%. Also in terms of quality, the most intense staining was in the ALM, and LM and NM had moderate staining intensity. With increasing depth of involvement, cox-2 stainingincreases. Intensity of cell staining was also higher in cases with tumor depth of 2-4 mm. Conclusion: The results indicate the effectiveness of cox-2 indifferentiating between malignant melanoma and benign melanocytic lesions. cox-2 expressioncorrelated with the depth of invasion. Although cox-2 alone cannot be used to differentiate melanoma from benign lesions, it can be helpful in combination with other methods, indetermining the prognosis and future targeted therapies |
| نویسنده | نفر چندم مقاله |
|---|---|
| عفت خدائیانی | اول |
| اشرف فخرجو | دوم |
| ارمغان قره آغاجی زارع | سوم |
| شهلا تلقینی | چهارم |
| مهدی امیرنیا | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 17286.pdf | 1399/07/20 | 472123 | دانلود |
