| Non-alcoholic fatty liver disease (NAFLD) is the well-known disease of the liver in adults and children throughout the world. Themain manifestations related to NAFLD are an unusual storage of lipid in hepatocytes (hepatic steatosis) and progression ofinflammation for non-alcoholic steatohepatitis (NASH). NAFLD is described as a multifactorial complication due to the geneticpredisposition, metabolic functions, inflammatory, gut microbiota (GM), and environmental factors. The GM dysregulationamong these factors is correlated to NAFLD development. In recent decades, advanced microbial profiling methods are con-tinuing to shed light on the nature of the changes in the GM caused by NASH and NAFLD. In the current review, we aim toperform a literature review in different library databases and electronic searches (Science Direct, PubMed, and Google Scholar)which were randomly obtained. This will be done in order to provide an overview of the relation between GM and NAFLD, andthe role of prebiotics, probiotics, and fecal microbiota transplantation (FMT), as potential therapeutic challenges for NAFLD. |