چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Aim:The purpose of this study was to design a metformin nanoparticles (NPs)-loaded buccoadhesive filmfor enhanced drug bioavailability.Materials & methods:The NPs were prepared and incorporated intoa hydroxypropyl methylcellulose-chitosan blend film. Three levels of a three-factor, Box–Behnken designwere used to evaluate the critical formulation variables. The drug permeation was also examined usingsheep buccal mucosa.Results & conclusion:The results verified the formation of spherical NPs with anaverage size of 177.8±6.42 nm and entrapment efficiency of 78.03±0.23%. The optimum conditions fornanofilms were predicted to be: hydroxypropyl methylcellulose (700 mg), glycerol (50 mg) and chitosan(0.15 %w/v). The nanofilm showed a high drug permeation within 6 h. The metformin nanofilm offersan excellent opportunity for buccal drug delivery. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سارا سلاطین | اول |
| میترا اعلمی میلانی | دوم |
| میترا جلوه گری | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| tde-2020-0066.pdf | 1399/07/18 | 2497345 | دانلود |
