| Computational epitope-based vaccine design is the cornerstone of vaccine development. Owing to the
selection of proper compositions [antigens (Ags), epitopes, peptide linkers, and intramolecular
adjuvants], epitope-based vaccines are considered a cost- and time-effective approach resulting in the
development of vaccines with maximal therapeutic efficacy and minimal adverse reactions. In this
review, we provide insights into in silico epitope-based vaccine design and highlight vaccinology
procedures used for the development of the next-generation vaccines with high effectiveness. |