چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background Long non-coding RNAs (lncRNAs) are a subset of non-coding RNAs. Abnormal expression of lncRNAs is associated with the development of cancers including gastric cancer (GC). Increasing evidence in this field reveals that lncRNAs have a key role in biological actions via modulating the expression of genes at various genomic levels. BC032913, as a novel antisense lncRNA, may have a role in GC progression. Objective The very aim of this study was to examine the clinical significance and the functional role of lncRNA BC032913 in GC. Methods QRT-PCR technique was exerted to survey the expression level of BC032913 in GC tissues and matched adjacent nontumorous tissues. Furthermore, the association between clinicopathological parameters and the expression level of BC032913 was evaluated. Results BC032913 expression was downregulated in cancerous tissues as compared with adjacent non-tumorous tissues (P = 0.0108). Downregulation of BC032913 expression did not demonstrate a significant association with clinicopathological parameters. Conclusion LncRNA BC032913 may be considered as an impressive therapeutic target for GC. |
| نویسنده | نفر چندم مقاله |
|---|---|
| میلاد اسدی | ششم |
| بهزاد برادران | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 436-BC032913 as a Novel Antisense Non-coding RNA is Downregulated.pdf | 1399/07/14 | 262721 | دانلود |
