| The solubility of mesalazine in {acetonitrile + water} mixtures was reported
at T = (293.2–313.2) K and correlated with some cosolvency models namely
van’t Hoff, Apelblat, Jouyban-Acree, Jouyban-Acree-van’t Hoff, combined
nearly ideal binary solvent/Redlich-Kister, modified Wilson, NRTL and
UNIQUAC models. The Yalkowsky and extended Yalkowsky models were
employed to predict the solubility data. The apparent thermodynamic
quantities of dissolution and mixing for mesalazine in aqueous acetonitrile
solutions were computed. Finally, preferential solvation analysis demonstrates
that mesalazine is preferentially solvated by water in almost all the
mixtures, except in the region 0.19 < x1 < 0.29. |