| The reported equilibrium mole fraction solubility of 4-(4-ethoxyphenyl)-
5-(3,4,5-trimethoxybenzoyl)-3,4-dihydropyrimidin-2(1H)-one (DHP-5) in some
{polyethylene glycol (PEG 400 (1) + water (2)} mixtures at 298.2 K has been
used to evaluate the preferential solvation of this compound by the mixture
components. First, molar volume andHildebrand solubility parameter of DHP-
5were calculated as 277.7 cm3 mol–1 and 25.11MPa1/2, respectively, by means
of Fedors’method. In this way, by using the inverse Kirkwood–Buff integrals
method, it is observed that this compound is preferentially solvated by PEG
molecules in all the mixtures. Thus, maximum preferential solvation parameter
by PEG was observed in the mixture x1 = 0.15 being 1.55 × 10 |