چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The main objective of this research was to determine and correlate the equilibrium solubility of sodium sulfadiazine in several {cosolvent (1) + water (2)} mixtures at 298.2 K. Cosolvents were formamide, N-methylformamide, N,N-dimethylformamide, dimethyl sulphoxide, N-methyl-2-pyrrolidone, 1,4-dioxane, and methanol. Classical shake-flask method was used to determine isothermal solubility. Drug concentration measurements were performed by means of electrical conductivity determinations after adequate aqueous dilutions. Solubility of sodium sulfadiazine decreases nonlinearly with the addition of cosolvent to water in almost all mixtures compositions. The Jouyban-Acree and Jouyban-Acree-Abraham models correlate the solubility values with the mixtures composition for all cosolvent systems. Furthermore, the apparent specific volume of this drug at saturation was also calculated from density and mixtures compositions. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ابوالقاسم جویبان | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Phys Chem Liq .pdf | 1399/07/14 | 1830480 | دانلود |
