چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The equilibrium solubility at five temperatures from (293.15 to 313.15) K, apparent dissolution, mixing and solvation thermodynamics, and apparent specific volume at saturation of acetaminophen (ACP) in {ethanol (EtOH) (1)+propylene glycol (PG) (2)+water (3)} mixtures is reported. Mole fraction solubility of ACP (x4) increases when temperature arises and also increases with the EtOH and/or PG proportions increasing. It varies from x4= 4.56 × 10−3 in the mixture 0.10–0.10-0.80 in mass fraction to x4=6.63×10−2 in the mixture 0.80-0.10-0.10 at 298.15 K. Solubility behavior was adequately correlated by Jouyban-Acree model and the obtained overall mean percentage deviations (MPD) of 4.0% (N=330). Moreover, the trained Jouyban-Acree model using a minimum number of experimental data points predicted the rest of data points with the MPD of ~5.0% (N=303). Fromthe variation of solubilitywith temperature the apparent thermodynamic analysis of dissolutionwas performed in all the ternary mixtures. Further, fromdensities of the saturated solutions and those of the cosolvent mixtures free of drug, the apparent specific volumes at saturation were also calculated. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ابوالقاسم جویبان | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| J Mol Liq 318 (2020) 114065.pdf | 1399/07/13 | 1216511 | دانلود |
