چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Shakeel et al. reported the equilibriumsolubility of apremilast (3) in some {transcutol (1)+water (2)} mixtures at several temperatures with some numerical correlation analysis. Nevertheless, no attempt was made to evaluate the preferential solvation of this compound by the solvents. In this communication the preferential solvation of apremilast in the saturated mixtures at 298.15 Kwas analyzed based on the inverse Kirkwood-Buff integrals as described in the literature. Apremilast is preferentially solvated bywater in water-rich mixtures (0.00 b x1 b 0.12) but preferentially solvated by transcutol in mixtures with composition 0.12 b x1 b 1.00. These results could be interpreted as a consequence of hydrophobic hydration around the non-polar groups of the solute in the former case. Moreover, in the last case, the observed trend could be a consequence of the acid behavior of apremilast in front to transcutol molecules because this cosolvent is more basic than water as described by the respective solvatochromic parameters |
| نویسنده | نفر چندم مقاله |
|---|---|
| ابوالقاسم جویبان | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| J Mol Liq 316 (2020) 113905.pdf | 1399/07/13 | 436061 | دانلود |
