| Nanotechnology, as a progressing field of science, is constantly expanding its role in biomedicine by introducing of novel nanoplatforms over time. Nanoscaled metal-organic frameworks (NMOFs) are porous hybrid solids made of organic ligands and metal ions that offer a powerful potential to revolutionize traditional nanocarriers due to their tunable structural features, high surface area, adjustable pore size, facile synthesis, biocompatibility, highly versatile composition, and high chemical stability. Among various types of NMOFs, the stimuli-responsive MOFs are efficient candidates for biomedical applications, because they are designed to specifically change their property upon exposure to interior stimuli in target tissues (e.g., pH and redox reaction triggering agents), or external stimuli like temperature, light and magnetic field. In this review, to fully address the field of stimuli-responsive MOFs as nanocarrier systems, we deliberate the basic chemistry of stimuli-responsive mechanisms of MOFs. Besides, we will report recent progress of MOF-based stimuli-responsive systems, including those responding to a single stimulus and multiple stimuli, which can provide an innovative vision for the designing of efficient controllable smart MOF nanocarriers upon different triggers. |