| Obesity and overweight are associated with the burden of chronic diseases. The aim
of the present meta-analysis is to determine the efficacy of spirulina in reducing of
obesity indices. PubMed, Web of Science, Scopus, EMBASE and Cochrane library
databases were searched up to November 2019. Randomized controlled trials comparing
spirulina supplementation with a placebo or no treatment for anthropometric
indices were included. Meta-analysis was performed using random-effects model.
Subgroup analysis and meta-regression were carried out. Publication bias was evaluated
using standard methods. Spirulina had ameliorative effects on weight
(WMD = −1.85 Kg; 95% CI: −2.44, −1.26; p < .001; I2 = 82.4%, p < .001), and waist
circumference (WMD = −1.09 cm; 95% CI: −2.16, −0.01; p = .046; I2 = 0.0%,
p = .757) while no significant effect was shown on body mass index, even after sensitivity
analysis (SMD = −0.53 Kg/m2; 95% CI: −1.25, 0.19; p = .149; I2 = 92.9%,
p < .001); however, spirulina was effective in studies lasted for at least 12 weeks
(SMD = −1.25 Kg/m2; 95% CI: −2.21, −0.28; p = .011; I2 = 90.8%, p < .001). Spirulina
supplementation exerts beneficial effects on weight and waist circumference. The
ameliorative effect of spirulina on body mass index was revealed in longer duration
of supplementation. |