چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The solubility of lamotrigine (LTG) was determined in {1-propanol (1) + water (2)} mixtures over a temperature range of 293.15 to 313.15 K. The measured data were correlated to cosolvency models namely Jouyban-Acree, Jouyban- Acree-van’t Hoff, combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), modified Wilson and Machatha models. Among the models, Jouyban-Acree with temperature and solvent composition dependencies has more accuracy rather than Jouyban-Acree-van’t Hoff model and CNIBS/R-K model with solvent composition dependency is more compatible with the experimental solubility data. Furthermore, the apparent standard molar Gibbs energy, entropy, and enthalpy of dissolution and mixing ΔH soln, ΔS soln, ΔG soln, ΔH mix , ΔS mix and ΔG mix for LTG in the studied binary mixtures were calculated based on the van’t Hoff and Gibbs free energy equations which suggest that the dissolution process is more favourable in 1-propanolrich mixtures and proceeds entropically. Finally, preferential solvation parameters of LTG by -propanol were also calculated by means of the inverse Kirkwood-Buff integrals. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد برزگر جلالی | اول |
| سیده نرجس میرحیدری | دوم |
| ابوالقاسم جویبان | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Phys Chem Liq 58 (2020) 432-445-1.pdf | 1399/07/12 | 1983201 | دانلود |
