چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| High-fat diet (HFD) intake is linked to chronic kidney disease. Farnesoid X receptor (FXR) controls the renal lipid metabolism and fibrosis. The purpose of the current study was to evaluate the possible impacts of trans-chalcone on HFD-induced changes in renal lipid metabolism and Smad-3 expression through the regulation of FXR expression. To this aim, 28 rats were randomly divided into control, chalcone, HFD, and HFD + chalcone groups. At the end of treatments, renal FXR, sterol regulatory element-binding protein (SREBP)-1c, fatty acid synthase (FAS), Smad-3, and neutrophil gelatinase-associated lipocalin (NGAL) expression levels were assayed. Moreover, insulin sensitivity check index (QUICKI) was calculated. trans-Chalcone significantly inhibited HFD-induced reduction of insulin sensitivity. Moreover, HFD decreased the FXR expression, and trans-chalcone reversed this change. trans-Chalcone also inhibited HFD-induced increases in expression levels of SREBP-1c, FAS, Smad-3, and NGAL. Therefore, trans-chalcone, as a renoprotective agent, inhibits HFD-induced disturbances in FXR/SREBP-1c/FAS and FXR/Smad-3 pathways. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمدرضا علیپور | اول |
| الهام کریمی ثالث | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| trans-Chalcone inhibits high-fat diet-induced disturbances in.pdf | 1399/07/11 | 452849 | دانلود |
