چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Abstract Background Pleasure from palatable foods can stimulate hedonic eating and, therefore, might be a major culprit for obesity. Dopamine receptor polymorphisms, especially variants in the genes regulating the D2 receptor, including ANKK1 and DRD2, are the prime candidates for assessing the individual diferences in hedonic eating. This study was carried out to investigate the possible associations of the T (rs1800497) and Del (rs1799732) alleles with body mass index (BMI) and hedonic hunger among Iranian Azeri women. Methods A total of 372 healthy overweight/obese subjects (BMI≥25 kg/m2 ) and 159 normal weight individuals (BMI 18.5–24.9 kg/m2 ) were genotyped for the polymorphisms of ANNK1 and DRD2 genes using PCR–RFLP. BMI and hedonic hunger were also evaluated. Results Three hundred and sixty-three (68.36%), 152 (28.63%), and 16 (3.01%) of the participants had CC, CT, and TT genotypes for ANNK1 gene, respectively. Of 515 samples genotyped for DRD2 gene, 315 (60.51%), 173 (33.59%), and 27 (5.24%) had Ins/Ins, Ins/Del, and Del/Del genotypes, respectively. The genotype and genotype frequencies were significantly diferent between the groups (p=0.04). Signifcant diferences were observed between the T+ genotype (TT+TC) and the T− genotype (CC) regarding the BMI and hedonic hunger scores (p<0.05). In addition, Del+ group (Del/Del+Ins/Del) had higher BMI and hedonic hunger scores compared to Del− group (Ins/Ins) (p<0.05). Conclusions Our fndings showed that the frequencies of T and Del alleles were greater in the overweight/obese individuals. Also, the polymorphism of ANKK1 (rs1800497) and polymorphism of the DRD2 gene (rs1799732) showed significant associations with BMI and hedonic hunger. Level of evidence Level III, case-control study |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرشته علی اصغری | اول |
| رضا مهدوی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Paper.pdf | 1399/07/09 | 680658 | دانلود |
