چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Purpose: Cancer is an example of the most important growing diseases in human society and scientists are trying to treat it without considerable side effects on patient’s health. Solid lipids are colloidal nanoparticles that were used in drug delivery due to their several advantages. Methods: In this work, surface modified targeted solid lipid nanoparticles were fabricated by nano-homogenizer using tripalmitin glyceride and stearic acid as lipid constituents. The size of nanoparticles and morphological evaluations were surveyed using particle size analyzer, scanning electron microscopy; Fourier transforms infrared spectroscopy (FT-IR) and differential scanning calorimetry. Results: The particle size of 148.5 and appropriate polydispersity index were achieved for lipid nanoparticles with an entrapment efficiency of 86.1%. The FT-IR analysis confirmed the coupling of lysine to the free functional group of SLNs. Differential scanning calorimetry proved the conjugation of amino acid to the surface of carriers. The in vitro Epirubicin release test exhibited the further controlled release phenomenon for the lysine conjugated nanoparticles. The cytotoxicity assay showed lower IC50 of lysine conjugated solid lipid nanoparticles of Epirubicin on the investigated cell line. Conclusion: These studies showed that the fabricated targeted carrier have a very remarkable anticancer effect on breast cancer cell lines in comparison with pure drug. |
| نویسنده | نفر چندم مقاله |
|---|---|
| جعفر عزتی نژاد دولت آبادی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy.pdf | 1399/07/08 | 957675 | دانلود |
