Lysine-embedded cellulose-based nanosystem for efcient dual-delivery of chemotherapeutics in combination cancer therapy

نویسندگان: ابوالفضل اکبرزاده , سویل واقفی مقدم , سودابه داوران , فاطمه عابدی , عفت علیزاده , بهزاد برادران

کلمات کلیدی: Combination therapy l-Lysine Nanocrystalline cellulose (NCC) Dual-drug delivery Sustained release Adjuvant drug Synergistic effect A B S T R A C T Combination therapy by two or multiple drugs with different mechanisms of action is a promising strategy in cancer treatment. In this regard, a wide range of chemotherapeutics has used simultaneously to achieve the synergistic effect and overcome the adverse side effects of single-drug therapy. Herein, we developed a biocompatible nanoparticle-based system composed of nanocrystalline cellulose (NCC) and amino acid L-lysine for efcient co-delivery of model chemotherapeutic methotrexate (MTX) and polyphenol compound curcumin (CUR) to the MCF-7 and MDA-MB-231 cells. The drugs could release in a sustained and acidic-facilitate manner. In vitro cytotoxicity results represented the superior anti-tumor efcacy of the dual-drug-loaded nanocarrier

نشریه: 6138 , 2020 , 250 , 2020