چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| We read with great interest the paper published by Gianfrancesco and colleagues in Annals of the Rheumatic Diseases in 2020.1 They examined demographic and clinical factors associated with COVID-19 hospitalisation status in people with rheumatic disease using 600 cases from 40 countries. In their multivariable model, it was found that prednisone dose ≥10 mg/day (OR: 2.05, 95% CI 1.06 to 3.96) and anti-tumour necrosis factor inhibitor use (OR: 0.40, 95% CI 0.19 to 0.81) were associated with odds of hospitalisation.1 Patients with autoimmune diseases (AD) are at an increased risk of infectious diseases due to the effects of the disease on the immune system function, much comorbidity caused by various comorbidities such as kidney and lung damage, diabetes mellitus and hypertension, as well as the chronic use of immunomodulatory drugs.2 3 Patients treated with immunomodulatory drugs are vulnerable to viral infections,3 4 and worse prognosis of COVID-19 is probable in patients with ADs5 that need to be studied. Here, we would like to share our study results that were conducted on patients with ADs treated with immunomodulatory drugs. In our single-centre retrospective study, charts of patients diagnosed with COVID-19 who were admitted to Imam Reza Hospital and were discharged or deceased were reviewed. Imam Reza Hospital is a referral centre for COVID-19 in the East Azerbaijan province, which is one of the high-risk areas in Iran. In this centre, patients with symptoms suggestive of COVID-19 who had oxygen saturation lower than 90% were admitted. Diagnosis was made using positive PCR or findings consistent with COVID-19 pneumonia based on chest CT scan and ruling out other causes of pneumonia. Disease outcomes were assessed based on the level of care, the time interval between the onset of symptoms and intubation, duration of intubation, duration of admission in intensive care unit (ICU) and the number of patients who died. For statistical analysis, we used SPSS V.16 software. Continuous variables with normal distribution were reported as mean±SD and non-normally distributed continuous variables were reported as median (25%–75% IQR). Categorical variables were reported as frequency and percentage. χ2 and independent samples t-test/Mann-Whitney U test were used to assess differences between groups of patients treated with or without immunomodulatory drugs. Four hundred and eleven patients who were diagnosed with COVID-19 pneumonia were included in this study. Thirty of these patients had ADs (figure 1). In the immunomodulatory drugs-naïve and treated with immunomodulatory drugs groups 69.9% and 62.5% of patients were PCR positive for COVID-19, respectively (p=0.615). The frequency of some clinical manifestations such as malaise, dyspnoea, myalgia, anosmia and taste loss was significantly higher in patients with ADs treated with immunomodulatory drugs compared with immunomodulatory drugs-naïve patients (p<0.05) (table 1). In addition, lymphopenia was found to be less prevalent in patients treated with immunomodulatory drugs (p=0.015). No significant differences were observed in the admission level, time interval between the onset of symptoms and intubation, duration of intubation, duration of admission in ICU and number of deceased patients in the two groups (table 1). Pablos et al reported 1.3-fold higher prevalence of hospital PCR+COVID-19 in patients with rheumatic diseases.6 Grasselli et al reported inflammatory diseases and suppression of immune system as the most common comorbidities in patients younger than 40 years with COVID-19 admitted to the ICU.7 To the best of our knowledge, no study has been conducted to assess the outcomes of COVID-19 in patients with ADs treated with immunomodulatory drugs in comparison with other patients. Our preliminary findings suggest that the severity and mortality of COVID-19 in patients with ADs treated with immunomodulatory drugs are probably not significantly different from the general population. |
| نویسنده | نفر چندم مقاله |
|---|---|
| خلیل انصارین | اول |
| علی تقی زادیه | دوم |
| سعید صفیری | سوم |
| آیدا مالک مهدوی | چهارم |
| شیرین رنجبر | پنجم |
| سهیل تیموری | ششم |
| مسعود آهنگری ملکی | هفتم |
| علیرضا خبازی اسکویی | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| annrheumdis-2020-218737.pdf.pdf | 1399/07/07 | 665021 | دانلود |
