Mitochondrial donation in translational medicine; from imagination to reality
Mitochondrial donation in translational medicine; from imagination to reality
نویسندگان: فرهاد بانی , امیر ضارب کهن , رضا رهبرقاضی
کلمات کلیدی: Stem cells, Mitochondrial transfer, Cellular mechanisms, Regenerative potential
نشریه: 18741 , 1 , 18 , 2020
| نویسنده ثبت کننده مقاله |
رضا رهبرقاضی |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز سلولهای بنیادی |
| کد مقاله |
73629 |
| عنوان فارسی مقاله |
Mitochondrial donation in translational medicine; from imagination to reality |
| عنوان لاتین مقاله |
Mitochondrial donation in translational medicine; from imagination to reality |
| ناشر |
6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Review Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| The existence of active crosstalk between cells in a paracrine and juxtacrine manner dictates specific activity under physiological and pathological conditions. Upon juxtacrine interaction between the cells, various types of signaling molecules and organelles are regularly transmitted in response to changes in the microenvironment. To date, it has been well-established that numerous parallel cellular mechanisms participate in the mitochondrial transfer to modulate metabolic needs in the target cells. Since the conception of stem cells activity in the restoration of tissues’ function, it has been elucidated that these cells possess a unique capacity to deliver the mitochondrial package to the juxtaposed cells. The existence of mitochondrial donation potentiates the capacity of modulation in the distinct cells to achieve better therapeutic effects. This review article aims to scrutinize the current knowledge regarding the stem cell’s mitochondrial transfer capacity and their regenerative potential. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| mito.pdf | 1399/07/04 | 3010220 | دانلود |