چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| At the end of 2019, a novel flu-like coronavirus named COVID-19 (coronavirus dis-ease 2019) was recognized by World Health Organization. No specific treatmentsexist for COVID-19 at this time. New evidence suggests that therapeutic optionsfocusing on antiviral agents may alleviate COVID-19 symptoms as well as those thatlead to the decrease in the inflammatory responses. Flavonoids, as phenolic com-pounds, have attracted considerable attention due to their various biologicalproper-ties.In this review, the promising effects and possible mechanisms of action ofnaringenin, a citrus-derived flavonoid, against COVID-19 were discussed. Wesearched PubMed/Medline, Science direct, Scopus, and Google Scholar databases upto March 2020 using the definitive keywords. The evidence reviewed here indicatesthat naringenin might exert therapeutic effects against COVID-19 through the inhibi-tion of COVID-19 main protease, 3-chymotrypsin-like protease (3CLpro), and reduc-tion of angiotensin converting enzyme receptors activity. One of the othermechanisms by which naringenin might exert therapeutic effects against COVID-19is, at least partly, by attenuating inflammatory responses. The antiviral activity of theflavanone naringenin against some viruses has also been reported. On the whole, thefavorable effects of naringenin lead to a conclusion that naringenin may be a promis-ing treatment strategy against COVID-19. |
| نویسنده | نفر چندم مقاله |
|---|---|
| هلدا توتونچی | اول |
| علیرضا استاد رحیمی | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| COVID-19.pdf | 1399/07/03 | 1109634 | دانلود |
