چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| onalcoholic fatty liver disease (NAFLD) has become the most common cause of liver dysfunction worldwide. Recently, some natural compoundshave attracted growing interest in the treatment of NAFLD. In this context, most attention has been paid to natural products derived from fruits,vegetables, and medicinal herbs. Naringenin, a natural flavanone, has been revealed to have pharmacological effects in the treatment of obesityand associated metabolic disorders such as NAFLD. The aim of this study was to examine the therapeutic effects of naringenin and its possiblemechanisms of action in the management of NAFLD and related risk factors. The current systematic review was performed according to theguidelines of the 2015 PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) statements. We searched PubMed/Medline,Science Direct, Scopus, ProQuest, and Google Scholar databases up until February 2020. Of 1217 full-text articles assessed, 36 studies met theinclusion criteria. The evidence reviewed in the present study indicates that naringenin modulates several biological processes related to NAFLDincluding energy balance, lipid and glucose metabolism, inflammation, and oxidative stress by different mechanisms. Overall, the favorable effectsof naringenin along with its more potency and efficacy, compared with other antioxidants, indicate that naringenin may be a promising therapeuticapproach for the management of NAFLD and associated complications. However, due to the lack of clinical trials, future robust human randomizedclinical trials that address the effects of naringenin on NAFLD and other liver-related diseases are crucial. Further careful human pharmacokineticstudies are also needed to establish dosage ranges, as well as addressing preliminary safety and tolerability of naringenin, before proceeding t |
| نویسنده | نفر چندم مقاله |
|---|---|
| فاطمه نائینی | اول |
| زهرا نامخواه | دوم |
| علیرضا استاد رحیمی | سوم |
| هلدا توتونچی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Main text.pdf | 1399/07/03 | 1278947 | دانلود |
