| Objectives: We aimed to evaluate the possible role of dietray TAC against different types of
cancers in a systematic review and meta-analyses of observational studies. Methods: A literature
search of authentic electronic resources had been performed to obtain the relevant
studies up to February 2020. Results: Twenty-one studies including nine prospective and
twelve case–control studies were included in the current systematic review and meta-analysis.
These studies have included 1404297 individuals. Higher TAC categories were associated
with 21% reduced risk of colorectal cancer, 27% reduced risk of endometrial cancer,
42% reduced risk of gastric cancer, and 32% reduced risk of pancreatic cancer. In meta-analysis
of prospective studies also highest category of TAC was associated with reduced incidence
of breast cancer (RR¼ 0.68; CI: 0.54, 0.86; P¼0.025), colon cancer (RR¼ 0.92; CI: 0.74,
1.16; P¼0.01), hepatocellular carcinoma (RR¼ 0.49; CI: 0.35, 0.69; P<0.001), gastric cancer
(RR¼ 0.65; CI: 0.50, 0.84; P¼0.001), lung cancer (RR¼ 0.90; CI: 0.85, 0.95; P¼0.001) while
increased risk of rectal cancer (RR¼ 1.02; CI: 0.69, 1.52; P¼0.005). Conclusion: Higher intake
of dietary TAC was in association with reduced risk of different types of cancers in metaanalysis
of observational studies. |