چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Selegiline (L-deprenyl) is the major drug which is used in the treatment of Parkinson’s disease because of its neurotrophic and antiapoptoticproperties.PreviousstudiessuggestedthatlowdoseofL-methamphetamine(L-METH)causedlowermortalityrate in patients with severe traumatic brain injury. As L-methamphetamine is one of the metabolites of selegiline, the present study aims to examine whether L-deprenyl can improve cognitive, biochemical, and histopathological injury in animal model of transient global ischemia. The animals were randomized in ten groups orally gavaged three times a week for 28 days. Then, novel objectrecognition(NOR) was conductedtoassesstheir behavioralabnormality.After scarification ofthe rats, their brains were divided into two sections to measure oxidative stress parameters and perform pathological evaluations in rats. Our data revealed the involvement of oxidative stress, behavioral despair, and pathological data in transient global ischemia rats. Significant recovery in cognitive behavior, oxidative stress biomarker, and number of dead cell in histopathological assay was observed in rats treated with 1,2 and 4 mg/kg of selegiline. So, selegiline appears to be useful in alternative therapy of transient global ischemia. |
| نویسنده | نفر چندم مقاله |
|---|---|
| جواد محمودی | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 10.1007_s12031-020-01544-5.pdf | 1399/06/26 | 1348086 | دانلود |
| xemqsxgvrw6wu0.pdf | 1399/06/31 | 614822 | دانلود |
