| Introduction: Acute pulmonary embolism (PE) is one of the deadly cardiovascular diseases.
One of the indexes proposed in these patients for risk stratification is the Thrombolysis in
Myocardial Infarction (TIMI) risk index (TRI), which includes three parameters of systolic blood
pressure, age, and heart rate. This study aimed to evaluate the predictive value of TRI on inhospital and 30-day mortality of PE patients.
Materials and Methods: This cross-sectional study included 345 patients who were
diagnosed with acute PE in Madani Heart Center from January 2012 to January 2017.
Demographic characteristics, hemodynamic findings upon first admission, type of treatment (i.e.,
thrombolytic, anticoagulant, or surgery), as well as in-hospital and 30-day outcomes were
recorded for all patients. The TRI and simplified Pulmonary Embolism Severity Index (PESI)
were calculated for all patients.
Results: The overall and in-hospital mortality rates were 8.7% and 8.1%, respectively. The
mortality group were significantly older and had significantly higher heart rates, cardiac
troponin levels, simplified PESI scores, and TRI followed by lower systolic blood pressure and
O2 saturation. Moreover, the TRI obtained specificity, sensitivity, positive, and negative
predictive values of 98.78%, 25.25%, 89.29%, and 76.66%, respectively, using receiver
operating characteristic curves and a cut-off value of 36.73. Using the multiple logistic
regression analysis we found that TRI>36.73, older age, higher heart rate and lower SBP could
predict 30-day mortality.
Conclusion: The results showed that the risk of in-hospital mortality is higher with an
increase in TRI. Furthermore, despite the high specificity, lower sensitivity limits its utility |