چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| A microwave-induced air–assisted liquid–liquid microextraction method has been proposed forthe pretreatment/quantization of salbutamol in exhaled breath condensate (EBC) samples prior togas chromatography-mass spectrometry. In this procedure, 1-fluoro-2,4-dinitrobenzene and N,N-diethylethanolammonium chloride: dichloroacetic acid: octanoic acid deep eutectic solvent wereexploited as derivatization reagent and extraction solvent, respectively. A mixture of the sample solutionand pyridine was transferred into a test tube. Then, a mixture of extraction solvent and derivatizationagent was placed at the bottom of the tube. After performing the predetermined extraction cycles in themicroextraction method, the mixture was exposed to microwave irradiations to enhance derivatizationand extraction efficiencies. The obtained turbid solution was centrifuged and a portion of the sedimentedphase was used for quantification of salbutamol. The validated method showed low limits of detection(0.074 and 0.370 g/L in deionized water and EBC, respectively), quantification (0.246 in deionized waterand 1.23 g/L in EBC), and lower limit of quantification (0.123 and 0.615 g/L in deionized water andEBC, respectively). The method had appropriate repeatability, accuracy, and stability (expressed as rela-tive standard deviation less than 9%). The developed method was used in quantification of salbutamol inthe real samples collected from donors receiving salbutamol spray. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ابوالقاسم جویبان | اول |
| مریم خوب نسب جعفری | سوم |
| وحید جویبان قراملکی | چهارم |
| محمدرضا افشار مقدم | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Salbutamol-DES-2020-published.pdf | 1399/06/17 | 1067475 | دانلود |
