چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Biocompatible drug delivery vehicleswith sustained drug release property are valuable in cancer therapy and can reduce some of the side effects.Hence, to achieve the biocompatible systemwith sustained drug release behavior a new drug carrier was fabricated via in situ synthesis of MIL-53 (MIL =Materials of Institute Lavoisier) within the carboxymethylcellulose/graphene quantum dots matrix (CMC/GQDs) as a biological macromolecule based platform(MIL-53@CMC/GQDs). Fourier transforminfrared (FT-IR), and X-ray diffraction (XRD) analysis revealed successful synthesis ofMIL-53@CMC/GQDs. The mean pore diameter ofMIL-53@CMC/GQDs obtained 18.66 nm. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) exhibited that MIL-53 is well distributed in hydrogel matrix. Doxorubicin (DOX) was loaded about 55.80% and 88.90% into the MIL-53 and MIL-53@CMC/GQDs, respectively. Drug release studies showed the pH-dependent DOX release behavior for DOX@MIL-53@CMC/GQDs. The cytotoxic assay approved the biocompatibility ofMIL-53@CMC/GQDs against the human breast cancer cell line (MDA-MB 231). The fragmentation of nuclei and condensation of chromatin after treatment with DOX@MIL-53@CMC/GQDs displayed its capability in cancer treatment.Moreover, an arrest in sub-G1 of cell cycle after treatment with MIL-53@CMC/GQDs showed cell's apoptosis. The results conveyed a new concept that the MIL-53@CMC/GQDs could be proposed as a potential carrier for the delivery. |
| نویسنده | نفر چندم مقاله |
|---|---|
| رویا صالحی قره ورن | سوم |
| دکتر حسن نمازی | دوم |
| ملیحه پوراسمعیل | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 116. Pouresmail, Int J Biol Macromol, 2020.pdf | 1399/06/04 | 5562552 | دانلود |
