چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Surface plasmon resonance (SPR) sensor provides a very useful tool based on its label-free, real-time monitoring and low price properties. However, measurement of small molecules and extremely diluted analytes is difficult and therefore, signal enhancement is required. In the present study, signal enhancement of erlotinib conjugated magnetic nanoparticles (erlotinib-MNPs) compared to erlotinib was evaluated via their interaction with overexpressed epidermal growth factor receptor on human lung cancer cells (A549 cell line) surface using SPR sensor at three temperature levels. The attained results showed an average signal amplification of about 2.5-fold for MNP-erlotinib interaction with A549 cells compared to erlotinib interaction with those cells. Overall, this signal enhancement method could be used for measurement of small molecules and cancer cell detection via interaction of their overexpressed receptor and various ligands. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سعیده محمدزاده اصل | اول |
| ایوب آقانژاد | دوم |
| جعفر عزتی نژاد دولت آبادی | چهارم |
| احمد کشتکار | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Surface plasmon resonance signal enhancement based on erlotinib loaded magnetic nanoparticles for evaulation of its interaction with human lung cancer cells.pdf | 1399/05/29 | 2025023 | دانلود |
