چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| In this work, a microwave–enhanced air–assisted liquid–liquid microextraction method combined with gas chromatography–mass spectrometry has been developed for morphine and oxymorphone assessment in EBC samples. For this purpose, choline chloride-menthol-phenylacetic acid deep eutectic solvent (as an extraction solvent), butyl chloroformate (as a derivatization agent), and picoline (as a catalyst) are used. After performing predetermined extraction cycles in the microextraction method, the obtained cloudy solution is exposed to microwave irradiations to enhance extraction and derivatization efficiencies. The method provided low limits of detection (morphine 2.1 and oxymorphone 1.5 ng mL−1) and quantification (morphine 7.2 and oxymorphone 5.2 ng mL−1) in the EBC samples. The method had proper repeatability, accuracy, and stability expressed as relative standard deviations less than 5.1, 9, and 9%, respectively. The developed method was successfully used to determine morphine and oxymorphone concentrations in the EBC samples of addict patients. |
| نویسنده | نفر چندم مقاله |
|---|---|
| فاطمه نوروزی | اول |
| مریم خوب نسب جعفری | دوم |
| وحید جویبان قراملکی | سوم |
| جعفر سلیمانی | چهارم |
| ابوالقاسم جویبان | پنجم |
| محمدرضا افشار مقدم | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Morphine-JCB.pdf | 1399/05/23 | 1459018 | دانلود |
