چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| A colorimetric nano-platform is reported for phenobarbital determination in human plasma samples. It is based on the inhibitory effect of phenobarbital on melamine induced aggregation of sodium dodecyl sulfate modified silver nanoparticles. The interaction of melamine and phenobarbital results in the disaggregation of nanoparticles and consequently increase the absorbance intensity proportional to phenobarbital concentration, and color change from purple to yellow. A central composite design as a multivariate optimization approach with four in- dependent parameters (i.e. pH, melamine concentration, nanoparticle concentration and time) was employed to optimize the reaction conditions. In the optimized conditions, the presented method was fully validated by inves- tigation of system linearity, sensitivity, accuracy, precision, and selectivity. The validated method was used for the determination of phenobarbital in plasma samples collected from patients receiving phenobarbital. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سمیرا زادعلی اصغر | اول |
| الهه رحیم پور | دوم |
| مریم خوب نسب جعفری | سوم |
| علی نخودچی | پنجم |
| ابوالقاسم جویبان | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| phenobarbital.pdf | 1399/05/11 | 977141 | دانلود |
| Ethics.pdf | 1399/05/11 | 589888 | دانلود |
