| KCC-1/Pr-SO3H is found to be a considerable efficient nanocatalyst for the one-pot threecomponent condensation coupling of aromatic aldehydes, isatoic anhydride, and primary
amines for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in ethanol as a green solvent
under reflux conditions with excellent yields. The influence of different reaction parameters
such as the effects of solvent, temperature, time, and concentration of catalyst for the
synthesis of 2,3-dihydroquinazolin-4(1H)-one (4f) were studied. KCC-1/Pr-SO3H is easily recyclable without the significant loss of catalytic activities after seven times. This mild and simple
synthesis method offers some worthwhile advantages including short reaction time, high
yield, and convenient work-up procedure. |