چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهدیه علیپور | اول |
| مرضیه آقازاده | دوم |
| ابوالفضل اکبرزاده | سوم |
| زهرا آقازاده | ششم |
| وحیده رییس دسته حکم آباد | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Presently, tissue engineering has been developed as an effective option in the restoration and repair oftissue defects. One of the tissue engineering strategies is to use both biodegradable scaffolds and stimu-lating factors for enhancing cell responses. In this study, the effect of zeolite was assessed on cell viability,proliferation, osteo/odontogenic differentiation, and mineralization of human dental pulp stem cells(hDPSCs) cultured on poly (e-coprolactone)–poly (ethylene glycol)-poly (e-caprolactone) (PCL-PEG-PCL)nanofibers. For this purpose, PCL-PEG-PCL nanofibrous scaffolds incorporated with zeolite were preparedvia electrospinning. Both PCL-PEG-PCL and PCL-PEG-PCL/Zeolite nanofibrous scaffolds revealed bead-lessconstructions with average diameters of 430nm and 437nm, respectively. HDPSCs were transferred toPCL-PEG-PCL nanofibrous scaffolds containing zeolite nanoparticles. Cell adhesion and proliferation ofhDPSCs and their osteo/odontogenic differentiation on these scaffolds were evaluated using MTT assay,Alizarin red S staining, and qRT-PCR assay. The results revealed that PCL-PEG-PCL/Zeolite nanofibrousscaffolds could support better cell adhesion, proliferation and osteogenic differentiation of hDPSCs andas such is expected to be a promising scaffold for bone tissue engineering applications. (9) (PDF) Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds. Available from: https://www.researchgate.net/publication/335164081_Towards_osteogenic_differentiation_of_human_dental_pulp_stem_cells_on_PCL-PEG-PCLzeolite_nanofibrous_scaffolds [accessed Jul 05 2020]. |
| کلمات کلیدی | Bone tissue engineering;nanofibrous scaffolds;zeolite; human dental pulpstem cells |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Zeolite.png | 1399/04/15 | 439451 | دانلود |
| Towards osteogenic differentiation of human dental pulp stem cells on PCL PEG PCL zeolite nanofibrous scaffolds(1).pdf | 1399/04/15 | 1557341 | دانلود |
