Intranasal ketamine versus intravenous morphine for pain management in patients with renal colic: a double‑blind, randomized, controlled trial
Intranasal ketamine versus intravenous morphine for pain management in patients with renal colic: a double‑blind, randomized, controlled trial
نویسندگان: محبوب پورآقائی , پیمان محرم زاده , سیدپویا پاک نژاد , زهرا وندرجب پور , حسن سلیمانپور
کلمات کلیدی: Ketamine · Morphine · Kidney stones
نشریه: 35025 , 0 , 0 , 2020
| نویسنده ثبت کننده مقاله |
حسن سلیمانپور |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات پزشکی مبتنی بر شواهد EBM |
| کد مقاله |
72710 |
| عنوان فارسی مقاله |
Intranasal ketamine versus intravenous morphine for pain management in patients with renal colic: a double‑blind, randomized, controlled trial |
| عنوان لاتین مقاله |
Intranasal ketamine versus intravenous morphine for pain management in patients with renal colic: a double‑blind, randomized, controlled trial |
| ناشر |
5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
خیر |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| Background Urinary stones are a common urologic problem that can be manifested as an intense pain, known as renal colic.
Pain control is an important intervention for the emergency treatment of renal colic patients. Intranasal ketamine can form
a crucial part of such interventions by ofering a new route for a widely-used analgesic drug.
Methods In a double-blind, randomized, clinical trial, adults with renal colic admitted to a tertiary hospital emergency
department were examined. The intervention group received 1 mg/kg intranasal (IN) ketamine and 1 ml of saline as a placebo.
The control group received 0.1 mg/kg intravenous (IV) morphine and four pufs of saline as the placebo. The pain score was
measured on the Numerical Rating Scale (NRS) 0, 15, 30 and 60 min after the drug administration.
Results A total of 184 patients enrolled in this study in two parallel groups. The two groups did not difer signifcantly in
terms of pain intensity at the time of their referral (P = 0.489), 15 min post-dose (P = 0.204), 30 min post-dose (P = 0.978)
and 60 min post-dose (P = 0.648).
Conclusion IN ketamine is as efective as IV morphine for pain control in renal colic patients. No remarkable side-efects
were observed for IN ketamine use in these patients. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| 41.pdf | 1399/04/08 | 503535 | دانلود |