چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Drug solubility studies in solvent mixtures have great importance in the pharmaceutical sciences especially in pharmaceutical technology. Advancements in thermodynamic modeling enable a better mechanistic understanding and can provide guidance in the development of promising solvent mixtures for a given drug. This work studied equilibrium solubility of 5-aminosalicylic acid (mesalazine) in mixed solvents using N-methyl-2- pyrrolidone (NMP) and water at T=(293.2 to 313.2) K. The obtained solubility data were described mathematically by the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, UNIQUAC and NRTL models. To discuss the solute-solvent interactions, the activity coefficients of mesalazinewere determined in the nvestigated mixtures. Calculation of the apparent thermodynamic properties of dissolution and mixing for mesalazine, as well as, the preferential solvation parameters in the studied mixtures provided valuable molecular insights into the studied model system and the results are of practical relevance in case of mesalazine. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ابوالقاسم جویبان | ششم |
| الناز مظاهرحاجی آقا | دوم |
| سالار همتی | سوم |
| کیمیا جویبان | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| J Mol Liq 310 (2020) 113143.pdf | 1399/04/03 | 1344140 | دانلود |
