| Although neurological symptoms are not frequent in coronavirus infection, the high number of patients
with SARS-CoV-2 infection may explain the presence of the virus in the central nervous system and
increase the likelihood of early- or delayed-onset neurological symptoms. It is highly possible that some of
these patients, particularly those who have a severe illness, have central nervous system involvement and
neurological manifestations. The mechanism of injury is not fully understood but SARS-CoV-2 via direct
infection, immune dysfunction, and hypoxemic injury as well as angiotensin-converting enzyme 2 receptors
can result in infectious toxic encephalopathy, viral encephalitis and acute cerebrovascular accident.
Personalized and targeted documentation of neurological symptoms, detailed clinical, neurological, and
electrophysiological assessment of the patients, attempts to isolate SARS-CoV-2 from cerebrospinal fluid,
and autopsies of the COVID-19 victims may clarify the role played by this virus in causing neurological
manifestations. In order to ensure optimum neurological patient management, ongoing study of treatment
algorithms will be essential for updating and adapting these approaches as the COVID-19 pandemic
evolves. In this review we discussed about the different neurologic manifestations of COVID-19 patients. |