چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The chitosan-based thermosensitive hydrogel is one of the attractive in situ forming drug delivery systems that are suggested for ophthalmic applications. However, the use of this thermogel has been limited by nontransparency, relatively low solubility and prolonged gelation time. In this study, a convenient approach has been reported to develop transparent thermosensitive hydrogel with suitable cytocompatibility and gelation properties for glaucoma treatment. After obtaining the optimum quaternization conditions, the developed insitu gelling formulation of quaternized chitosan was achieved by mixing sodium hydrogen carbonate with β- glycerophosphate as a gelling agent. The formulation was a solution below or at room temperature and turned to a transparent hydrogel around ocular surface temperature within several minutes. The results of thermal and rheological evaluations demonstrated that adding sodium hydrogen carbonate has a synergic effect in enhancing the thermosensitivity of the hydrogel. Also, the prepared hydrogels based on quaternized chitosan presented obvious porous architectures, good swelling, and degradability. Hemolysis and cytotoxicity evaluations suggested that the developed hydrogels indicated good biocompatibility as a drug carrier. Finally, the in vitro release profile of timolol maleate as an anti-glaucomamodel drug showed the initial burst release in the early hours and a steady linear release of drug fromthe hydrogel over 1week. The obtained results confirmed that the developed hydrogel can be considered as an efficient drug delivery candidate for glaucoma therapy. |
| نویسنده | نفر چندم مقاله |
|---|---|
| یوسف پاک زاد | اول |
| مرضیه فتحی | دوم |
| یداله امیدی | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Pakzad-IJBM.pdf | 1399/03/18 | 3097050 | دانلود |
