Improvement of delivery and anticancer activity of doxorubicin by sildenafil citrate encapsulated with a new redox and pH-responsive nanogel
Improvement of delivery and anticancer activity of doxorubicin by sildenafil citrate encapsulated with a new redox and pH-responsive nanogel
نویسندگان: مرجان قربانی , لیلا روشنگر , مجتبی زارعی
کلمات کلیدی: Doxorubicin; gold
nanoparticle; nanogel;
sildenafil citrate;
stimuli-responsive
نشریه: 15324 , 14 , 69 , 2020
| نویسنده ثبت کننده مقاله |
مرجان قربانی |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز سلولهای بنیادی |
| کد مقاله |
72394 |
| عنوان فارسی مقاله |
Improvement of delivery and anticancer activity of doxorubicin by sildenafil citrate encapsulated with a new redox and pH-responsive nanogel |
| عنوان لاتین مقاله |
Improvement of delivery and anticancer activity of doxorubicin by sildenafil citrate encapsulated with a new redox and pH-responsive nanogel |
| ناشر |
5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
|
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| Resistance to anticancer drugs and their incomplete delivery to the cancerous tissue are the main
causes of the chemotherapy failure. In this regard, colloidal systems offer a promising prospect to
deal with these concerns. So, in this study, we tried to formulate and optimize
Doxorubicin@Sildenafil citrate-coloaded with a new hybrid of PEGylated stimuli-responsive nanogel/gold nanoparticles (DOX@SC-coloaded PNG/gold NPs) to overcome multidrug resistance (MDR)
limitation and improve delivery to the cancerous tissue. Our Results confirmed that co-delivery of
DOX and SC which promotes internalization of drugs by integrin mediated endocytosis and ABC
transporter inhibition. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| Ghorbani,2020,56 2.pdf | 1399/04/29 | 3006383 | دانلود |
