Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease
Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease
نویسندگان: صفر فرج نیا , فاطمه محسنی , رقیه باغبان
کلمات کلیدی: NAFLD, rs780094 polymorphism, Biochemical parameters, Demographic parameters
نشریه: 55078 , 1 , 13 , 2020
| نویسنده ثبت کننده مقاله |
صفر فرج نیا |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات کاربردی دارویی |
| کد مقاله |
72370 |
| عنوان فارسی مقاله |
Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease |
| عنوان لاتین مقاله |
Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease |
| ناشر |
5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
|
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح دو – PubMed |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| Objective: GCK rs780094 polymorphism is a single nucleotide polymorphism that has been associated with obesity,
type II diabetes and dyslipidemia in some populations, conditions that highly related to NAFL etiology. The present
study aimed to evaluate the relationship between NAFLD and rs780094 polymorphism in patients with NAFLD in
Tabriz city, northwest of Iran. The rs780094 polymorphism was determined in 74 patients with NAFLD by PCR–RFLP
technique. Demographic information was collected using a questionnaire and biochemical analysis was performed
using standard laboratory methods.
Results: There was a signifcant diference between case and control subjects for alanine aminotransferase, aspartate aminotransferase, HDL-C and triglycerides (P<0.05). Analysis by PCR–RFLP method revealed that there were no
signifcant diferences between NAFLD and healthy subjects for rs780094 polymorphism in the study population. The
results of this study indicated that rs780094 polymorphism is not associated with NAFLD in subjects from Tabriz city |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| GCK paper -grant.pdf | 1399/03/10 | 890452 | دانلود |