چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Multiple sclerosis is immune-mediated disease of the central nervous system characterized by demyelination in axons. IFN-β is first-line treatment of MS. Biomarkers are needed for early prediction of responders and nonresponders to therapy in the first month of treatment to avoid further disabilities. In this study, we analyzed the expression level of miR-504 and miR-711 in 52 IFN-β responder patients in comparison to 53 non-responders. In the next step, the in-silico analysis was used to enrich related signaling pathways. The expression level of miR- 504 was significantly higher in patients who respond to IFN-β therapy, compared with non-responders and we obtain related statistically significant KEGG molecular signaling pathways. Our findings suggest that miR-504 can be considered as a novel biomarker for response to IFN-b therapy. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهسا طهماسبی وند | اول |
| سید رضا موسوی | دوم |
| هرمز آیرملو | چهارم |
| رضا ریخته گر غیاثی | پنجم |
| بهاره خادمی | هفتم |
| زهرا بهمن پور | هشتم |
| بابک امامعلی زاده | نهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 37- mir504,320.pdf | 1399/03/10 | 1564751 | دانلود |
