چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Advanced glycation end products (AGEs) are destructive molecules in the body that, at high levels, contribute tothe progression of various chronic diseases. Numerous studies have suggested a modifying effect of vitamin D onAGEs and their receptors. This study sought to summarize the effects of vitamin D on AGEs and their receptors,including receptor for AGEs (RAGE) and soluble receptor for AGEs (sRAGE). The search method initiallyidentified 484 articles; 331 remained after duplicate removal. Thirty-five articles were screened and identified asrelevant to the study topic. After critical analysis, 27 articles were included in thefinal analysis. Vitamin Dtreatment may possibly be beneficial to reduce AGE levels and to augment sRAGE levels, particularly in vitaminD-deficient situations. Treatment with this vitamin may be effective in reducing RAGE expression in somedisease conditions, but might be even harmful under normal conditions. The inhibitory or stimulatory effects ofvitamin D on AGE receptors are mediated by various signaling pathways, MAPK/NF-κB, ADAM10/MMP9 andAT1R. In populations with chronic diseases and concomitant hypovitaminosis D, vitamin D supplementation canbe used as a strategy to ameliorate AGE-mediated complications by modifying the AGE-RAGE and sRAGE sys-tems. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ثریا خیروری | اول |
| محمد علی زاده | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Vit.D & AGEs.pdf | 1399/03/06 | 738413 | دانلود |
