چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Objective: Non-alcoholic fatty liver disease (NAFLD) is one of the main risk factors for cardiovascular mortality and morbidity. This study, for the first time, explored the effects of trans-chalcone on cardiac expressions of myocardial fibrosis-related genes, including transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF/CCN2), and collagen type I. Materials and methods: Twenty-eight rats were randomly divided into four groups: control, received 10% tween 80; chalcone, received trans-chalcone; HFD, received high-fat diet (HFD) and 10% tween 80; HFD+chalcone, received HFD and trans-chalcone, by once-daily gavage for 6 weeks. Finally, cardiac expression levels of TGF- β 1, CTGF, and collagen type I were determined. Results: HFD feeding increased mRNA levels of collagen type I, TGF- β 1, and CTGF in the heart of rats. However, trans-chalcone inhibited HFD-induced changes. Conclusions: trans-Chalcone can act as a cardioprotective compound by inhibiting TGF- β 1 and CTGF dependent stimulation of collagen type I synthesis in the heart of HFD-fed rats. |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام کریمی ثالث | اول |
| محمدرضا علیپور | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| trans Chalcone inhibits transforming growth factor 1 and connective tissue growth factor dependent collagen expression in the heart of high fat diet (1).pdf | 1399/02/29 | 942034 | دانلود |
