چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سید کاظم میری نژاد | اول |
| سید یعقوب مودب | دوم |
| امیرطاهر افتخارسادات | سوم |
| مسعود شیرمحمدی | چهارم |
| محمد حسین صومی | ششم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Survival ,Familial Adenomatous Polyposis, colorectal cancer, Iran |
| خلاصه مقاله | Introduction: Familial adenomatous polyposis (FAP) is an autosomal dominant disorder. Colorectal cancer (CRC) has been implicated as the most common cause of death in FAP patients, especially in those with coexisting CRC at initial diagnosis (FAP-CRC). Aim: We aimed to determine the survival rate of FAP-CRC and the factors affecting FAPCRC survival. Methods: This was a retrospective cohort FAP study conducted in northwest Iran. From 2006 to 2016, 51 FAP-CRC individuals were selected from among 4588 CRC patients. Statistical analysis: A Student’s t-test, life table method, log-rank tests, a Kaplan-Maier survival curve and Cox regression analysis were performed and a value of p < 0.05 was set as significant. Results: A total of 51 FAP-CRC patients were selected, (30 males, 21 females), with a mean age of 42.2 years at diagnosis. The most common presenting symptom was abdominal pain and the most common primary tumor site was the rectum. The 1-, 5- and 10-year overall survival rates were 76%, 59%, and 52%, respectively. Factors affecting the FAP-CRC survival rate, namely sex, age at CRC diagnosis, and extra colonic manifestations (ECM), showed no significant differences. The difference in 5-year survival rates between patients with colon and rectal cancers was significant (75% vs. 33%, P = 0.02). The survival rate was significantly higher among patients with disease stages I and II than those in disease stages III and IV (P = 0.001). Five-year survival rates in patients with ileal pouch-anal anastomosis (IPAA) and ileorectal anastomosis (IRA) were 71% and 78%, respectively (P = 0.001). There was an interesting difference in survival between FAP and attenuated familial adenomatous polyposis (AFAP) (P = 0.01). In Cox regression analysis, distant metastasis was a significant predictor of survival (P = 0.001). Conclusion: Long-term survival from FAP-CRC remains poor; therefore, early stage detection and the choice of an appropriate surgical method can improve survival in such patients. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| certificate-ICGH 2017.pdf | 1399/02/28 | 80722 | دانلود |
| Abstract Book ICGH 2017.pdf | 1399/02/28 | 4549492 | دانلود |
