Survival Rate and Prognostic Factors of Esophageal Cancer in East Azerbaijan Province, North-west of Iran

Survival Rate and Prognostic Factors of Esophageal Cancer in East Azerbaijan Province, North-west of Iran


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نویسندگان: سید کاظم میری نژاد , محمد حسین صومی , امیر قاسمی جنگجو , فرشاد سید نژاد , سعید دستگیری , محمد محمدزاده , علیرضا ناصری , بهنام نصیری مطلق

کلمات کلیدی: Esophageal cancer - survival - prognosis - Kaplan-Meier - Cox proportional hazard model - Iran

نشریه: 3607 , 7 , 13 , 2012

اطلاعات کلی مقاله
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نویسنده ثبت کننده مقاله سید کاظم میری نژاد
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه بیماری های گوارش و کبد
کد مقاله 72209
عنوان فارسی مقاله Survival Rate and Prognostic Factors of Esophageal Cancer in East Azerbaijan Province, North-west of Iran
عنوان لاتین مقاله Survival Rate and Prognostic Factors of Esophageal Cancer in East Azerbaijan Province, North-west of Iran
ناشر 8
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ بلی
عنوان نشریه (خارج از لیست فوق)
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت

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Background: Esophageal cancer in Iran is the sixth most common cancer and is particularly important in east Azerbaijan. The aim of this study was to calculate survival rates and defne prognostic factors in esophageal cancer patients. Methods: In this study, all patients with esophageal cancer registered in the Radiation Therapy Center, during March 2006 to March 2011, were analyzed and followed up for vital status. Data were analyzed using the Kaplan-Meier method and the Cox proportional hazard models. Results: Out of 532 patients, survival information was available for 460, including 205 (44/ 5%) females and 255 (55/4%) males. The mean age was 65.8±12.2, ranging from 29 to 90 years at the time of diagnosis. 1- , 3- and 5-year survival rates after diagnosis were 55%, 18% and 12%, respectively, with a median survival time of 13.2 ± .7 (CI 95% =11.8 -14.6) months. In the univariate analysis, age (P=0/001), education (P=0/001), smoking status (P= 0/001), surgery (P= 0/001), tumor differentiation (P= 0/003) and tumor stage (P= 0/001) were signifcant prognostic factors. Tumor morphology, sex, place of residence, tumor histology and tumor location did not show any signifcant effects on the survival rate. In multivariate analysis, age (P = 0/003), smoking (P= 0/01) and tumor stage (P= 0/001) were signifcant independent predictors of survival. Conclusion: In summary, prognosis of esophageal cancer in North West of Iran is poor. Therefore, reduction in exposure to risk factors and early detection should be emphasized to improve survival.

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نویسنده نفر چندم مقاله
سید کاظم میری نژاداول
محمد حسین صومیدوم
امیر قاسمی جنگجوسوم
فرشاد سید نژادچهارم
سعید دستگیریپنجم
محمد محمدزادهششم
علیرضا ناصریهفتم
بهنام نصیری مطلقهشتم

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Survival rate and prognostic factors of esophageal cancer in east Azerbaijan province, North-west of Iran..pdf1399/02/22375136دانلود