| Background: Esophageal cancer in Iran is the sixth most common cancer and is particularly important in
east Azerbaijan. The aim of this study was to calculate survival rates and defne prognostic factors in esophageal
cancer patients. Methods: In this study, all patients with esophageal cancer registered in the Radiation Therapy
Center, during March 2006 to March 2011, were analyzed and followed up for vital status. Data were analyzed
using the Kaplan-Meier method and the Cox proportional hazard models. Results: Out of 532 patients, survival
information was available for 460, including 205 (44/ 5%) females and 255 (55/4%) males. The mean age was
65.8±12.2, ranging from 29 to 90 years at the time of diagnosis. 1- , 3- and 5-year survival rates after diagnosis
were 55%, 18% and 12%, respectively, with a median survival time of 13.2 ± .7 (CI 95% =11.8 -14.6) months. In
the univariate analysis, age (P=0/001), education (P=0/001), smoking status (P= 0/001), surgery (P= 0/001), tumor
differentiation (P= 0/003) and tumor stage (P= 0/001) were signifcant prognostic factors. Tumor morphology,
sex, place of residence, tumor histology and tumor location did not show any signifcant effects on the survival
rate. In multivariate analysis, age (P = 0/003), smoking (P= 0/01) and tumor stage (P= 0/001) were signifcant
independent predictors of survival. Conclusion: In summary, prognosis of esophageal cancer in North West
of Iran is poor. Therefore, reduction in exposure to risk factors and early detection should be emphasized to
improve survival. |