چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | جواد محمودی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات علوم اعصاب |
| کد مقاله | 72154 |
| عنوان فارسی مقاله | Silk protein exhibits anti-depressant and anxiolytic properties through regulation of cerebral oxidative stress, neuroinflammation and apoptosis in a mouse model of spatial restraint stress |
| عنوان لاتین مقاله | Silk protein exhibits anti-depressant and anxiolytic properties through regulation of cerebral oxidative stress, neuroinflammation and apoptosis in a mouse model of spatial restraint stress |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | بیست و چهارمین کنگره ملی و سومین کنگره بینالمللی فیزیولوژی و فارماکولوژی |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2019 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/08/08 الی 1398/08/10 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://cong24.phypha.ir/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Neurosciences Research Center, Tabriz University of medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرشته فرج دخت | دوم |
| احد بناگذار محمدی | سوم |
| سعید صدیق اعتقاد | چهارم |
| سید مهدی وطن دوست | پنجم |
| جواد محمودی | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background and objectives: Chronic stress induces a wide range of neurochemical and neurobehavioral alternations, resulting in mood disturbances. This study examined the effects of silk protein (Sericin), on anxiety- and depressivelike behaviors, oxidative stress, inflammation, and apoptosis in the prefrontal cortex (PFC) and hippocampus (HIP) of spatial restraint stress-subjected mice. Materials and methods: Mice were randomized into 5 groups: control, restraint stress (RS), RS+ sericin100, RS+sericin150, and RS+sericin200. Animals in the stress groups were subjected to chronic spatial restraint stress (3 h/day for 21 days). Sericin-treated mice were received sericin (100, 150, and 200 mg/kg/day, gavage for 21 days) along with immobilization. Anxiety-like behaviors were assessed by elevated plus maze (EPM) and open field test (OFT), and depressive-like behaviors were evaluated by the forced swim test (FST) and tail suspension test (TST). Serum levels of corticosterone, mitochondrial membrane potential (MMP), and markers of oxidative stress, proinflammatory cytokines, and apoptosis-related proteins were evaluated in the PFC and HIP regions. Results: Silk Sericin prolonged time spent in open arms of EPM apparatus and increased number of central entries in OFT. Moreover, it reduced immobility time in TST and FST. Furthermore, sericin decreased ROS and MDA levels, restored MMP, and enhanced total antioxidant capacity and enzyme activity of GPx and SOD, and decreased NF- êB, TNF-á, and IL-1â levels in HIP and PFC Additionally, sericin reduced corticosterone concentration and inhibited mitochondrial-dependent apoptosis pathway. Conclusion: These findings provide evidence for the protective effect of sericin therapy against neurochemical and behavioral changes induced by restraint stress. |
| کلمات کلیدی | Spatial restraint stress, Depression and anxiety-like behaviors, Sericin, Neuroinflammation, Apoptosis Oxidative stress |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Final_Booklet98-10-17.pdf | 1400/01/11 | 3828763 | دانلود |
| Phypha-Mahmoudi J.pdf | 1399/02/19 | 117867 | دانلود |
| Phypha.mahmoudij.jpg | 1399/02/19 | 2631240 | دانلود |
