چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are life‑threatening parasitic infections worldwide caused by Echinococcus granulosus(sensu lato) and E. multilocularis, respectively. Very little is known about the factors afect‑ ing innate susceptibility and resistance to infection with Echinococcusspp. Although benzimidazolic drugs against CE and AE have defnitively improved the treatment of these cestodes; however, the lack of successful control cam‑ paigns, including the EG95 vaccine, at a continental level indicates the importance of generating novel therapies. This review represents an update on the latest developments in the regulatory functions of innate immune pathways such as apoptosis, toll‑like receptors (TLRs), and infammasomes against CE and AE. We suggest that apoptosis can recip‑ rocally play a bi‑functional role among the host‑Echinococcusmetabolite relationships in suppressive and survival mechanisms of CE. Based on the available information, further studies are needed to determine whether the orches‑ trated in silicostrategy for designing inhibitors and interfering RNA against anti‑apoptotic proteins and TLRs would be efective to improve new treatments as well as therapeutic vaccines against the E. granulosusand E. multilocularis |
| نویسنده | نفر چندم مقاله |
|---|---|
| نیر مهدی زاد بختیار | اول |
| عادل اسپوتین | دوم |
| محمود محامی اسکوئی | سوم |
| احسان احمدپور | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| document(16).pdf | 1399/02/17 | 1369594 | دانلود |
