چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Cytokines as important mediators have a critical role in appropriate immune responses which irregular production of the mediators can lead to Multiple Sclerosis (MS). Proinflammatory cytokine interleukin-1 (IL-1), trigger inflammatory responses. Function and production of the cytokine are influenced by IL-1 coding gene polymorphism and those antagonists gene polymorphism. Objective: The aim of the present study was to evaluate the possible correlation between MS and IL-1 related alleles in Azeri population of Iran. Method: Variable number tandem repeats (VNTR) genotypes of 150 MS patients and 220 healthy non-relative controls were determined. Results: In the healthy controls, genotype TT at IL-1A (-889) location was significantly higher than the MS patients (p=0.0001). However, a significant difference was not found between the two groups in genotypic/allelic frequency at IL- 1B+ 3953 location. Evaluation of the IL-1RA gene revealed that genotype 1/2, and genotype 1/3 were significantly higher in the healthy controls and MS patients, respectively. Our findings indicated that the consumption of fast-food in MS patients was significantly higher than controls (p= <0.05). Also, a considerable number of MS patients had inappropriate dieting behaviors such as not eating breakfast (p= 0.0001), and irregular eating habits (p= 0.0001). Conclusions: Polymorphisms of the IL-1B genes and common alleles of IL-1RA were not considered as risk factors for MS disease. However, genotype TT at IL-1A (-889) location and the rare allele of IL-1RA3 can be a potential risk factor for the disease. Furthermore, inappropriate dieting behaviors and consumption of fast-food can increase the risk of MS. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد اصغرزاده | اول |
| زهرا اشرفی جیقه | دوم |
| حسین صمدی کفیل | سوم |
| مهدی فرهودی | چهارم |
| داریوش سوادی اسکوئی | پنجم |
| فاطمه خاکی خطیبی | ششم |
| منوچهر فدائی | هفتم |
| علی وقاری | هشتم |
| وحید اصغرزاده | نهم |
| نیما نجفی قلعه لو | دهم |
| بهروز مهدوی پور صباحی | یازدهم |
| جلیل راشدی | دوازدهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Article.pdf | 1399/02/14 | 141237 | دانلود |
