چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| بهرام جمالی قراخانلو | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Objectives:Coronary artery disease is now the leading cause of death worldwide. An early sign of atherosclerosis is the accumulation of cholesterol-loaded macrophages (foam cells) in the intima of arteries. An elevated plasma level of low-density lipoproteins (LDL) is a risk factor for atherosclerosis, mainly because this lipoproteins deposit cholesterol within cells of the arterial wall . Numerous epidemiological studies have also demonstrated that plasma levels of high-density lipoproteins (HDL), and their major protein constituent apolipoprotein A-I (apoA-I) are inversely correlated with the risk of atherosclerosis. Moreover, rising HDL cholesterol inhibits atherogenesis in several genetic animal models. This protective effect of HDL-C against atherosclerosis is due to the HDL-C role in reverse cholesterol transport (RCT). In RCT, HDL-C mediates the removal of excess free cholesterol from peripheral cells to the liver for excretion as bile. Method: Participants were 36 obese women which randomly assigned into control and experimental groups. The experimental group performed 12 weeks of aerobic exercise and the control group remained sedentary. Blood samples were collected 24 hours before the first session and 48 hours after the last session (participants were fasting). The APOA1 gene expression were measured using semi-quantitative-RT-PCR. Data were analyzed by SPSS software (version 18). Results: A significant increase in lymphocyte Apo A-I gene expression was shown following the 12 weeks of training. Conclusions: Aerobic exercises can increase APO -A1 gene expression. Induction of these genes can effectively prevent cardiovascular disease. |
| کلمات کلیدی | APOA1, Aerobic exercise, Woman |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| sokhanrani+urmia.pdf | 1399/02/10 | 528735 | دانلود |
| URMIA.jpg | 1399/02/10 | 217272 | دانلود |
