| Background: Hospital-acquired infections are among the most
significant reasons of human mortality world-wide which can be
controlled by efficient application of suitable disinfectant for hospital
setting. The main goal of the present study was to determine the
efficacy of eight routinely used hospital disinfectants against clinical
isolates.
Methods: In our descriptive study, in the first step the antibiogram
assay of 99 clinical isolates enterococci and Pseudomonas aeruginosa
were determined. Then, minimum inhibitory concentration and
minimum bactericidal concentration of isolates against Povidone
Iodine 10%, Ethanol 70%, Savlon 3.2%, Deconex51Gastro, Procept
Floor, Septo med, Surfanious and Gigasept AF were evaluated.
Furthermore, the efficacy of disinfectants was reevaluated in presence
of 5% (w/v) Bovine Serum Albumin.
Results: The results showed that Septo med and Surfanious are the
most and less potent disinfectants against clinical isolates,
respectively. It is also resulted that Povidone Iodine is the most
effective choice among the conventional disinfectants in this study.
Clearly, addition of 5% organic substances reduced the efficacy of
selected disinfectants significantly.
Conclusion: Novel quaternary ammonium compounds are the most
applicable choice for disinfection of hospital surfaces and instruments
in this study. |