چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The solubility of ketoconazolewas measured in aqueousmixtures of 1,4-dioxane at T=(293.2 to 313.2) K using the shake flaskmethod. To mathematically represent the generated solubility data, combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, UNIQUAC, and NRTL models were applied. Differences of experimental and predicted values were expressed as the percentage of averaged relative deviation (% ARD). Apparent hermodynamic quantities of ketoconazole dissolution and mixing were reported at harmonic temperature. Moreover, the dissolution mechanism of ketoconazole was studied in 1,4-dioxane + water mixtures. Based on the inverse Kirkwood-Buff integrals, the preferential solvation parameters were calculated and it is observed that ketoconazole is preferentially solvated by water in water-rich and 1,4-dioxane-rich mixtures. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ابوالقاسم جویبان | ششم |
| محمد برزگر جلالی | اول |
| الناز مظاهرحاجی آقا | دوم |
| خسرو ادیب کیا | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| J Mol Liq 306 (2020) 112830.pdf | 1399/02/02 | 1189539 | دانلود |
