چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | سمانه حسینی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات علوم اعصاب |
| کد مقاله | 71889 |
| عنوان فارسی مقاله | ارزیابی تشخیصی سندرم ایزوله رادیولوژیکی |
| عنوان لاتین مقاله | Approach to Radiologically Isolated Syndrome |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | 16th Iranian International Congress on Multiple Sclerosis |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | مشهد |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2019 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/08/22 الی 1398/08/24 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://cong-ms16.mums.ac.ir/fa/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Neurosciences Research Center, Tabriz university of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| سمانه حسینی | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Approach to Radiologically Isolated Syndrom Okuda and colleagues defined unanticipated brain spatial dissemination of MRI lesions highly suggestive of MS in the absence of characteristic clinical signs and symptoms attributable to central nervous system (CNS) demyelination, as Radiologically Isolated Syndrome. The McDonald criteria for MRI dissemination in time (DIT) (gadolinium-enhancing lesions and/or new T2 lesions), as described in the MAGNIMS MRI criteria, could further improve the identification of RIS subjects with a high risk of developing neurological symptoms and will allow a definite diagnosis of MS once the subject shows a seminal neurological event suggestive of CNS demyelination. The most predictive risk factors for conversion of RIS to CIS/MS are at least an asymptomatic cervical spine cord lesion, younger age, male gender, contrast enhancing lesions, abnormal VEP and CSF oligoclonal bands. The most strongest one is the spinal cord lesion. Within 5 years, one third of RIS patients convert clinically to CIS, RRMS, or PPMS, one third will have radiological activity but no clinical symptoms, and one third will remain radiologically and clinically stable. Although a few studies have previously reported predictors of RIS conversion to CIS/MS, the key predictors are unclear. Spinal cord MRI and CSF biomarker analysis should be performed in all RIS patients because they are associated with high likelihood of early conversion from RIS to MS. As treating RIS patients remains controversial to date, physicians may be inclined to offer prophylactic treatment to high-risk RIS patients with a more definitive prognosis to prevent disease conversion. Current evidence does not support initiation of disease modifying therapy before the development of the first demyelinating clinical event. |
| کلمات کلیدی | Radiologically isolated syndrome, approach, high risk |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
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| Untitled.png | 1400/02/06 | 92556 | دانلود |
| scan0002 (1).jpg | 1400/02/06 | 757557 | دانلود |
| Approach to Radiologically Isolated Syndrome.docx | 1399/11/23 | 13251 | دانلود |
