چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد مرشدی | اول |
| الهه سادات حسینی فرد | دوم |
| خدیجه باوفا | سوم |
| مریم ثقفی اصل | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | anxiety and depression-like behavior; amygdala; Lactobacillus Plantarum; inulin; oxidative stress |
| خلاصه مقاله | Background and Aim: Type 2 diabetes mellitus (T2DM) can lead to major complications such as psychiatric disorders which includes depressive and anxiety-like behaviors. The association of the gut–brain axis in the development of such disorders, especially in T2DM has been elucidated; however, gut dysbiosis is also reported in patients with T2DM. Hence, the regulation of the gut–brain axis, in particular, the gut–amygdala, as a vital region for the regulation of behavior is essential.Methods: Thirty-five male Wistar rats were divided into six groups. To induce T2DM, treatment groups received HF diet and 35mg/kg STZ. Then, supplements of Lactobacillus Plantarum, inulin or their combination were administered to each group for 8 weeks. Finally, the rats were sacrificed for measurement of blood and tissue parameters after behavioral testing.Results: The findings demonstrated the favorable effects of the psychobiotics (L. plantarum, inulin or their combination) on oxidative markers of the blood and amygdala (SOD, GPx, MDA and TAC), as well as on concentrations of amygdala serotonin and brain-derived neurotrophic factor (BDNF) in the diabetic rats. In addition, beneficial effects were observed on the elevated plus maze (EPM) and forced swimming tests (FST) with no change in locomotor activity of the rats. There was a strong correlation between the blood and amygdala oxidative markers and depressive and anxiety-like behaviors.Conclusion: Our results identified L. plantarum ATCC 8014 and inulin or their combination as novel psychobiotics that could have improving the systemic and nervous antioxidant status and improving amygdala performance and beneficial psychotropic effects. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| morshedi1.jpg | 1399/01/31 | 327655 | دانلود |
| Beneficial Psychotropic Effects.pdf | 1399/02/08 | 630509 | دانلود |
